“Stress-resilience impacts psychological wellbeing as evidenced by brain–gut microbiome interactions”

From Dr. Marco Ruggiero

HIGH STRESS-RESILIENCE IS ASSOCIATED WITH A HEALTHY MICROBIOME

An article in Nature Mental Health titled “Stress-resilience impacts psychological wellbeing as evidenced by brain–gut microbiome interactions” cited the growing evidence that the gut and brain work together to build resilience to stress, suggesting that the gut is a possible pathway to help prevent or minimize stress-related psychiatric conditions.

The study identified a specific composition of gut microbiome linked to a “high-resilience phenotype” characterized by microbes and metabolites promoting anti-inflammatory effects and supporting gut-barrier integrity. People with this phenotype reported lower anxiety and depression symptoms.

The researchers went beyond just analyzing gut bacteria. They also employed clinical assessments, psychological evaluations, and MRI scans to examine brain structure and function. 

Their findings suggest that the “the microbiome is critical in shaping resilience and modifying the gut microbiome can optimize mental health.”

UNDERSTANDING STRESS

The study’s lead author, Ms. Arpana Church, an associate professor at UCLA’s David Geffen School of Medicine, emphasizes the importance of understanding the body’s response to stress in preventing and reducing both mental and physical health problems. Church highlights the prevalence of stress in the United States, pointing out that a significant portion of the population experiences stress-related physical symptoms, and a substantial number reports experiencing extreme stress.

“Usually in medicine, we really focus on disease, how to cure disease, how to better understand the underlying mechanism of disease, and what I wanted to do was flip the script, said Ms. Church. This study focused instead on health and the microbiome characteristics of resilient people.

RESILIENCY EQUATES TO HEALTH 

The study revealed clear distinctions in the gut microbiome composition between those with high and low stress resilience. Individuals with high resilience exhibited biomarkers associated with better gut-barrier integrity, reduced risk of depression and anxiety, better cognitive function, and healthier brain structure with increased functional connectivity.

The findings support the link between a weakened gut barrier, often referred to as “leaky gut,” and chronic health issues. Additionally, the study reinforces the connection between gut microbiome imbalance, known as dysbiosis, and both chronic diseases and inflammation.

Analysis of the gut microbiome in the high-resilience individuals noted increased levels of microbes and metabolites that are:

– Better at environmental adaptation

– Able to replicate and repair DNA

– Better at carbohydrate and energy metabolism

– Endowed with anti-inflammatory properties

Beyond the gut microbiome, the study also investigated psychosocial factors. Church and her team found that individuals with high stress resilience displayed personality traits like greater acceptance, agreeableness, kindness, and extroversion, along with a tendency towards mindfulness, lower perceived stress, and lower levels of neuroticism.

Church described the relationship between the gut and the brain like a car with working brakes. “If you have great working brakes, you’re able to modulate or control the situation, have emotional regulation and cognitive response,” she said. 

CLINICAL IMPLICATIONS

This research paves the way for a more comprehensive understanding of resilience, potentially leading to novel mental health interventions. Traditionally, resilience has been viewed as a psychological characteristic linked to a person’s control, determination, and cognitive coping skills. However, maintaining these strategies requires significant metabolic resources. By examining stress through a broader lens that incorporates the gut microbiome, the study empowers both practitioners and patients.

The findings highlight the intricate interplay between gut bacteria, brain plasticity (neuroplasticity) and the body’s response to stress, offering a more holistic view of resilience adaptations. The gut microbiome produces metabolites, including neurotransmitters like serotonin and GABA, which significantly influence stress-related mental health conditions.

HOPE FOR THE FUTURE AND AVAILABLE SOLUTIONS

The study opens doors for potential mental health interventions centered on improving gut health. Similar to how we might increase vitamin C intake to combat an oncoming cold, this research suggests that supporting gut health through an appropriate combination of probiotics, prebiotics, and postbiotics could be a viable approach.

The encouraging aspect lies in the modifiable nature of these factors. Unlike some mental health challenges, the gut microbiome and many lifestyle choices are within our control. By incorporating practices that promote a healthy gut and brain microbiome, as well as positive behavioral changes, we can significantly enhance our resilience.

The two-way communication between the gut and brain (bi-directional relationship) highlights the potential for a holistic approach that empowers individuals to take charge of their well-being through microbiome-targeted interventions.

Bravo Yogurt

More than meets the gut!!!

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