The Science of Bravo – Oleic Acid, Deglycosylated Vitamin D-Binding Protein, Nitric Oxide: A Molecular Triad Made Lethal to Cancer

Posted on August 23, 2016 by Mimi Castellanos

Oleic Acid, Deglycosylated Vitamin D-Binding Protein, Nitric Oxide: A Molecular Triad Made Lethal to Cancer

Abstract. Background: Oleic Acid (OA) has been shown to have anticancer properties mediated by interaction with proteins such as α-lactalbumin and lactoferrins. Therefore, we synthesized complexes of OA and Gc protein-derived macrophage activating factor (GcMAF) that inhibits per se cancer cell proliferation and metastatic potential. We hypothesised that OA-GcMAF complexes could exploit the anticancer properties of both OA and GcMAF in a synergistic manner. We postulated that the stimulating effects of GcMAF on macrophages might lead to release of nitric oxide (NO). Patients and Methods: Patients with advanced cancer were treated at the Immuno Biotech Treatment Centre with OA- GcMAF-based integrative immunotherapy in combination with a low-carbohydrate, high-protein diet, fermented milk products containing naturally-produced GcMAF, Vitamin D3, omega-3 fatty acids and low-dose acetylsalicylic acid. Results: Measuring the tumour by ultrasonographic techniques, we observed a decrease of tumour volume of about 25%. Conclusion: These observations demonstrate that OA, GcMAF and NO can be properly combined and specifically delivered to advanced cancer patients with significant effects on immune system stimulation and tumour volume reduction avoiding harmful side-effects.

It is well-assessed that Oleic Acid (OA), a recognised fundamental component of healthy diets (1), shows anticancer properties (2) that contribute to the increase in

longevity and reduced risk of mortality and morbidity associated with its consumption (1). Although the precise molecular mechanism responsible for its anticancer properties is not completely understood (2), it appears that OA is involved in intracellular calcium signalling associated with the induction of cancer cell apoptosis.

It has been proposed that the anticancer effects of OA are mediated by its interaction with proteins highly represented in biological fluids such as α-lactalbumin and lactoferrins. These proteins bind OA to form OA-protein complexes which exhibit highly selective anti-tumour activity in vitro and in vivo (3). Soon after their identification, these complexes were labelled as HAMLET an acronym that stands for “human α-lactalbumin made lethal to tumour cells”, even though further studies demonstrated that α- lactalbumin is not the sole protein forming such complexes. Thus, other proteins, forming complexes with OA, exhibit identical anticancer properties (4). It is now accepted that these OA-protein complexes destroy tumour cells with high selectivity and with no evidence of toxicity for normal tissues, a key feature in the quest for anticancer treatments devoid of toxic side effects.

Study of the structural characteristics of such anticancer OA-protein complexes demonstrated that a common molecular feature is the tendency toward OA-induced protein oligomerization. Since OA-induced oligomerization has been reported for a number of proteins in addition to those initially identified in HAMLET, it was hypothesised that this phenomenon may be inherent to many proteins (5).

Some of the proteins forming OA-protein anticancer complexes such as α-lactalbumin and lactoferrins are highly represented in milk. These compounds are known to exert powerful stimulatory effects on the immune system (6). These findings provide additional acceptance to the hypothesis that the immune system is directly involved in the overall anticancer effects of OA-protein complexes.

The Article is here: Anticancer Res lavoro

 

This entry was posted in Most Recent. Bookmark the permalink.

948 Responses to The Science of Bravo – Oleic Acid, Deglycosylated Vitamin D-Binding Protein, Nitric Oxide: A Molecular Triad Made Lethal to Cancer

  1. Pingback: 918kiss

  2. Pingback: pg slot

  3. Pingback: 918kiss

  4. Pingback: Queen Arwa University ROR ID: 03ygqq617

  5. Pingback: First Yemeni University to Enter the Times Higher Education Impact Rankings 2024

  6. Pingback: Queen Arwa University Journal

  7. Pingback: Kampus Tertua

  8. Pingback: cheap sex cams

  9. Pingback: sex shows

  10. Pingback: cheap sex chat

  11. Pingback: san francisco jobs

  12. Pingback: baghdad jobs

  13. Pingback: joker gaming

  14. Pingback: frenchie for sale texas

  15. Pingback: stranger chat

  16. Pingback: online chat rooms

  17. Pingback: chatrandom text

  18. Pingback: itsmasum.com

  19. Pingback: itsmasum.com

  20. Pingback: itsmasum.com

  21. Pingback: Nangs delivery sydney

  22. Pingback: nangs delivery in Sydney

  23. Pingback: nangs sydney

  24. Pingback: FÜHRERSCHEIN KAUFEN

  25. Pingback: deux catégories de logiciel malveillant

  26. Pingback: ingénieur informaticien salaire

  27. Pingback: itsMasum.Com

  28. Pingback: itsMasum.Com

  29. Pingback: itsMasum.Com

  30. Pingback: itsMasum.Com

  31. Pingback: contratar sicario

  32. Pingback: 300 win mag ammo

  33. Pingback: 450 bushmaster ammo

  34. Pingback: drops to lose weight

  35. Pingback: apply evisa online

  36. Pingback: dietary supplements

  37. Pingback: hotel on lake placid

  38. Pingback: upstate hotels

  39. Pingback: Dating Coach in London

  40. Pingback: download aplikasi slot gacor

  41. Pingback: Raahe Guide

  42. Pingback: Raahe Guide

  43. Pingback: cybersécurité

  44. Pingback: la bonne paye règle

  45. Pingback: AI Lawyer

  46. Pingback: leak detection london

  47. Pingback: pg slot

  48. Pingback: french bulldog fashion

  49. Pingback: Best acne skincare products

  50. Pingback: หวย24

  51. Pingback: 918kiss

  52. Pingback: allgame

  53. Pingback: web designer Singapore

  54. Pingback: nangs delivery sydney

  55. Pingback: One Peace AMV

  56. Pingback: Slot Barat

  57. Pingback: 늑대닷컴

  58. Pingback: Alienlabs Agent

  59. Pingback: abogado fiscalista

  60. Pingback: Juicio de nulidad fiscal

  61. Pingback: efos y edos

  62. Pingback: rare breed-trigger

  63. Pingback: live sex cams

  64. Pingback: live sex cams

  65. Pingback: live sex cams

  66. Pingback: french bulldog buy

  67. Pingback: dog probiotics

  68. Pingback: fullersears.com

  69. Pingback: fullersears.com

  70. Pingback: fullersears.com

  71. Pingback: OnOverseas.Com

  72. Pingback: cheap sex cams

  73. Pingback: Generator Repair near me Manchester

  74. Pingback: FiverrEarn

  75. Pingback: FiverrEarn

  76. Pingback: FiverrEarn

  77. Pingback: FiverrEarn

  78. Pingback: FiverrEarn

  79. Pingback: FiverrEarn

  80. Pingback: FiverrEarn

  81. Pingback: FiverrEarn

  82. Pingback: FiverrEarn

  83. Pingback: FiverrEarn

  84. Pingback: Kuliah Termurah

  85. Pingback: Scientific Research

  86. Pingback: Situs Slot Online

  87. Pingback: Private University Yemen

  88. Pingback: web design

  89. Pingback: email

  90. Pingback: Lightroom Presets

  91. Pingback: Dairy

  92. Pingback: სერიალები ქართულად

  93. Pingback: filmebi qartulad

  94. Pingback: FiverrEarn

  95. Pingback: FiverrEarn

  96. Pingback: FiverrEarn

  97. Pingback: FiverrEarn

  98. Pingback: FiverrEarn

  99. Pingback: FiverrEarn

  100. Pingback: FiverrEarn

  101. Pingback: FiverrEarn

  102. Pingback: FiverrEarn

  103. Pingback: FiverrEarn

  104. Pingback: FiverrEarn

  105. Pingback: FiverrEarn

  106. Pingback: FiverrEarn

  107. Pingback: FiverrEarn

  108. Pingback: FiverrEarn

  109. Pingback: FiverrEarn

  110. Pingback: FiverrEarn

  111. Pingback: FiverrEarn

  112. Pingback: french bulldog texas

  113. Pingback: FiverrEarn

  114. Pingback: FiverrEarn

  115. Pingback: FiverrEarn

  116. Pingback: FiverrEarn

  117. Pingback: FiverrEarn

  118. Pingback: FiverrEarn

  119. Pingback: FiverrEarn

  120. Pingback: live sex cams

  121. Pingback: live sex cams

  122. Pingback: live sex cams

  123. Pingback: FiverrEarn

  124. Pingback: FiverrEarn

  125. Pingback: FiverrEarn

  126. Pingback: FiverrEarn

  127. Pingback: FiverrEarn

  128. Pingback: FiverrEarn

  129. Pingback: FiverrEarn

  130. Pingback: Tips

  131. Pingback: french bulldog pups for sale near me

  132. Pingback: How many years is pharmacy in Egypt

  133. Pingback: fue

  134. Pingback: fluxactive complete official website

  135. Pingback: menorescue reviews

  136. Pingback: biofit official site

  137. Pingback: partners

  138. Pingback: Unisex Trendy Custom Tees/Apparel

  139. Pingback: Pupuk terbaik dan terpercaya hanya melalui pupukanorganik.com

  140. Pingback: Aussie porn

  141. Pingback: FiverrEarn

  142. Pingback: FiverrEarn

  143. Pingback: FiverrEarn

  144. Pingback: Video Promo AL Zaytoonah University OF Jodran

  145. Pingback: FiverrEarn

  146. Pingback: FiverrEarn

  147. Pingback: FiverrEarn

  148. Pingback: Streamer

  149. Pingback: FiverrEarn

  150. Pingback: FiverrEarn

  151. Pingback: FiverrEarn

  152. Pingback: FiverrEarn

  153. Pingback: Fiverr

  154. Pingback: Fiverr.Com

  155. Pingback: Fiverr.Com

  156. Pingback: FiverrEarn

  157. Pingback: FiverrEarn

  158. Pingback: FiverrEarn

  159. Pingback: FiverrEarn

  160. Pingback: FiverrEarn

  161. Pingback: Classic Books 500

  162. Pingback: Entrepreneurship and innovation programs in Egypt

  163. Pingback: pcfinancial ca activate

  164. Pingback: Furniture protection

  165. Pingback: Packing services

  166. Pingback: Discreet moving

  167. Pingback: Storage solutions

  168. Pingback: FUE

  169. Pingback: FUE

  170. Pingback: FUE

  171. Pingback: FUE

  172. Pingback: FUE

  173. Pingback: FUE

  174. Pingback: FUE

  175. Pingback: FUE

  176. Pingback: FUE

  177. Pingback: FUE

  178. Pingback: Professional piano movers

  179. Pingback: Piano restoration experts

  180. Pingback: Piano relocation

  181. Pingback: Piano refurbishing

  182. Pingback: Warranty

  183. Pingback: Lean

  184. Pingback: bulldog frenchie puppies

  185. Pingback: isla mujeres golf cart rental

  186. Pingback: Fiverr

  187. Pingback: FiverrEarn

  188. Pingback: Fiverr

  189. Pingback: Fiverr.Com

  190. Pingback: FiverrEarn

  191. Pingback: Fiverr

  192. Pingback: Fiverr

  193. Pingback: french bulldogs

  194. Pingback: seo company tampa

  195. Pingback: SEOSolutionVIP

  196. Pingback: best university Egypt

Leave a Reply

Your email address will not be published. Required fields are marked *