I have studied about chronic fatigue syndrome, fibromyalgia, cancer, and diabetes. They all have something in common! They all have to do with cells that have been cut off from energy. It sums up to a self-imposed, inner oppression and makes us feel like someone is sitting on us. Well, our cells feel like that too.
I was in the Doctor’s office for my physical and I was looking at this chart on the wall. I am always “up” for a lesson. Here is what I saw and what I learned.
If you look at the chart, the left side of the cell is healthy, the right side isn’t. The cell wall and the cell receptor cites are the key. They are letting things flow on the healthy side. The unhealthy side is stuck. That is how my little oppressed cells feel too!
There is no energy within the cells that don’t have open passage through the cell wall. The nutrition would be glucose to the cells. Within the cell receptor cites, the communication hormones of insulin are blocking the way in and out inhibiting the flow. On the healthy cell it is handling (processing) the circulation of food and waste in and out of the body! Without this flow, we have aging, fatigue, muddled thinking and dirty blood.
Here we have an oriental medicine correlation. The cell wall is the same as the body skin and the diaphragm. All of which have three layers: Facing the world, facing the inner family life, and the middle layer is the processor or information.
The chart was “teaching me” something, but I knew it was my spiritual spidey sense under the veil of normal life that was coming forward to say, “look right here”. I came to an understanding of the emotional state of overwhelm and the cells of the pancreas.
I was “shown” that my cell receptors, (the left side of the cell wall) was blocked the same way it is on the image (see attached). I realized that my pancreas area cells were low energy in the same way this image is.
Today, I had time to work with it. Basically, the sugar I take in, is not getting into my cells. The sugar is in my blood stream where it shouldn’t be and is damaging my tissue just like this chart says, only not to the massive extent that Diabetes Type 2 would experience it. Clearly, my cells are under nourished causing various effects because my body can’t be as bright and shiny as I want it to be. The cells aren’t getting their food.
When I explored why this happened, I saw myself collapsed and pushing everything away because I was overwhelmed. No, I don’t want to do more or even to take time for myself. I just wanted to work to make money (more energy), because I have too many bills to pay, boo hoo hoo. I basically pulled negativity into me like a security blanket. (the diabetis beads into the cell receptor sites were a symptom of that)
Now, what I have to do is open up! I need to feel the flow of life go through me again! I open up the cell, clear out the cell receptor sites and begin to process the sugar again.
This is a work in process but if I never post it and begin, I risk loosing this sweet information and the way out!
Things that make a significant difference!
Do not toxify your body. Your microbes will want to cover them up and deaden the intensity as well as keep them alive in sugar and wax such as nuts, chocolate, cheese, etc. Instead stay with dark green leafy vegetables and heavy proteins. Processing your discomfort is a gift to yourself. Be present and get strong. (Like any exercise, it doesn’t feel good at first) DO IT.
Water. Without hydration the body can’t and won’t function. Not drinking enough water changes everything for the worse or better depending on the “line”. Lights off or Lights on. Take your body weight and divide it by 2. Then drink that in ounces per day. Work from there and make sure to stay ABOVE that line.
Oils Coconut oil and later fresher seed oils are available to you and should be used even if you don’t understand or feel it. The liver cleans you with oils. Not using them is like taking a shower without soap. It’s okay, kind of. NOT. Use oils for your cells to clean themselves. Fresher and more alive the better. Look in this site for coconut oil posts and cellular oppression posts.
Purified B7 helps the fat receptors to burn fats. Its as if it clears the interference and resets the function.
PQQ (Pyrroloquinoline Quinone)
•Supports healthy mitochondrial structure and function to help maintain healthy mental functions
•Clinical research is showing PQQ may protect brain health well into advanced years
•Promotes healthy structure and function of the mitochondria, the energy centers of cells
PQQ (Pyrroloquinoline quinone) is a relatively newly discovered vitamin-like nutrient related to the B-vitamin family. This natural compound found in an array of healthy foods displays antioxidant activity and neuro-protective actions that make it ideal for cognitive support. Studies suggest PQQ supports healthy mitochondrial structure and function to help maintain healthy mental functions like recall, memory and cognition as we age.
PQQ has been shown to be at least 100 times more efficient than vitamin C and all phenolic compounds tested to date in redox cycling potential.1
PQQ is found in beans, potatoes, parsley, green tea and fermented foods, and it’s also found in quite high amounts in human breast milk. In the body, PQQ is concentrated in vital organs that require high amounts of energy for optimal performance—organs like the brain and heart. Not surprisingly, PQQ is active within cellular mitochondria, the energy centers of cells. This has major implications for brain health, nervous system health and potentially other systems, structures and functions throughout the body, as it also displays antioxidant activity, neuroprotective action and cognitive benefits.
The breadth of PQQ’s potential benefits is nothing short of amazing. PQQ has been described as combining some of the best chemical features of vitamins C, B-2 and B-6 (reducing potential, redox reactions and carbonyl reactivity, respectively) into one molecule.2 In this way, PQQ is capable of acting directly as an antioxidant and then being recycled by glutathione back into an active form, substantially extending its antioxidant capabilities.
Current research on PQQ is looking into how it may benefit brain health specifically, as scientists believe the brain is at most risk of mitochondrial function decline. In the research, PQQ has been shown to support healthy mitochondria as well as something called nerve growth factor, which is essential for the growth and maintenance of healthy neurons and branching nerve cells. This means PQQ may prove helpful in maintaining healthy brain function well into our advanced years.
Suggested Use: As a dietary supplement, take 20mg per day with water.
A “typical” review found on line
Jarrow review from amazonAs one who has struggled with brain fog for many years, I have to say, no supplement has been more instrumental in relieving me of its burden. Within four days of starting a course of this supplement, I noticed SIGNIFICANT improvements in the clarity of my thoughts, and no longer did my mental energy fluctuate throughout the day. After several weeks of use, my state of mind is much clearer, and I’m no longer plagued by the prospect of not being able to operate at my highest level cognitively. This supplement should be in the arsenal of any one who want to ward off minor cognitive impairment and ensure that they’re able to stay cognitively fit and competitive in the workplace and establish their highest potential in their own quality of life. PQQ is a lifesaver for me; thanks to high quality and excellent prices, I’ll be using it as long as they sell it. AMAZING PRODUCT!
Your kidney strength is very important to the brain! Clean blood relieves sluggishness. Kidneys clean the blood. Berberis supports the kidneys.
I made this remedy for myself. You are welcome to try it for yourself.
“Breakthrough Discovery for Mitochondrial Health: Berberine and PQQ”
The latest science reveals exciting new roles for two less known supplements, crucial to the round-the-clock workings of your mitochondria. Who would ever suspect that a valuable metabolic master switch and a component of interstellar stardust may be one of the most important combinations ever for your mitochondria health?
As you’re well aware, your body grows older with each passing day. But did you know that the ‘battery’ driving your body’s aging is your mitochondria – those powerful energy factories within your cells?
For the first time, researchers have proven that mitochondrial function is associated with cell aging.
In a recent study, a research team successfully ‘tricked’ older cells into eliminating their damaged mitochondria until all were removed. They were stunned to discover that once these older cells shed their worn out, damaged mitochondria, they resembled younger cells!
These newly rejuvenated cells displayed levels of oxygen free radicals and expression of genes typical of more youthful cells.
This and similar studies confirm three important key points about how your mitochondria influences age-related changes in your body:
As you grow older, your mitochondria undergo damage and mutations that affect how well they function
Damaged mitochondria accumulate in cells
Your cells produce fewer new mitochondria as you age
Healthy mitochondria are essential to your health. They produce 95 percent of your body’s energy in the form of ATP, and they are also responsible for essential apoptosis or programmed cell death.
Your mitochondria also provide important signaling molecules for the expression of your genes, and they help promote a normal inflammatory response throughout your body.
Your mitochondria are so powerful, many experts believe they largely determine how long you live!
What You Don’t Know About Your Mitochondria Could Be Disastrous for Your Health
Many people are surprised to learn that they have two different types of DNA, or two sets of genetic blueprints, inside their cells.
The first type, your cellular or nuclear DNA, is what likely comes to mind when you think of your cells’ genetic material.
But you have another whole set of genetic material, and, as we’ve just learned, this DNA may actually determine your longevity.
Unlike the other components inside each of your cells, your mitochondria have their own DNA. And considering some of your cells can contain as many as 2,500 mitochondria, that’s a lot of genetic material!
Having their own DNA means your mitochondria have the ability to replicate and increase their numbers inside each of your cells.
Scientists now realize that the greater the number of mitochondria in your body and the healthier their functioning, the greater your odds are of living a healthy, long life.
But here’s the problem with your mitochondrial DNA… It’s far more susceptible to severe oxidative damage than your cellular DNA.
Because your mitochondria create 95 percent of the energy for your body’s processes, they sit in the midst of an enormous firestorm of oxidative activity. This continuous activity unleashes damaging free radicals and toxic reactive oxygen species.
Your mitochondrial DNA doesn’t have the same structural defenses and repair systems as your cellular DNA. So the genetic material in your mitochondria mutates at a much faster pace and accumulates in your body as you age.
Scientists are now convinced that damaged mitochondria and mitochondrial dysfunction are important contributors to the normal aging process and can affect your health.
What’s Harming Your Mitochondria?
When you’re younger, your mitochondria are well protected by your body’s natural defenses. As you age, that protection fades. The older you get, the faster your mitochondria deteriorate and become dysfunctional.
Mitochondrial dysfunction is most striking in high energy-demanding tissues and organs like your brain, heart, and muscles.
Studies show that brain cells in those over 70, on average, contain 50 percent more mitochondrial damage that do brain cells of middle-aged adults.
Besides cellular oxidative activity, diet is one of the biggest factors that influence the health of your mitochondria.
What you eat can make or break your mitochondria!
Your mitochondria are nourished by certain fuels and harmed by others. So, a healthy diet is one that supports mitochondrial function and prevents dysfunction.
Most people worldwide who eat a primarily processed food diet are burning carbohydrates as their primary fuel.
Burning carbs for fuel shuts down your body’s ability to burn fat. I believe this is why so many people find it nearly impossible to lose weight and keep it off.
When your body burns primarily carbs for fuel, excessive reactive oxygen species (ROS) and secondary free radicals are created, which damage cellular mitochondrial membranes and DNA.
When you eat a low net carb (total carbs minus fiber) diet with adequate protein and high in healthy fats – or a cyclical ketogenic diet – you can reach a state called nutritional ketosis where your body burns fat as its primary fuel, instead of sugar.
In ketosis, your body regains its metabolic flexibility to burn fat for fuel and your liver creates water-soluble fats called ketones that burn far more efficiently than carbs.
Why a Cyclical Ketogenic Diet May Be Your Mitochondria’s Best Friend
Becoming an efficient fat burner through ketosis is one of the most important strategies you can implement for your mitochondria – and your health.
‘Clean burning’ ketones create far fewer reactive oxygen species and secondary free radicals to damage your cellular and mitochondrial DNA, membranes, and proteins.
Ketones also mimic the lifespan-extending properties of calorie restriction or fasting, which includes optimal glucose metabolism.
As beneficial as a ketogenic diet is for your mitochondria, I don’t recommend staying on it for an extended period.
Once you’re able to burn fat for fuel, I suggest switching over to a cyclical ketogenic diet, or feast-famine.
At that point, you begin cycling in and out of nutritional ketosis by upping your carb and protein intake once or twice a week.
Surprisingly, by periodically “pulsing” or consuming a higher carb intake – say, 100 or 150 grams of carbs opposed to 20 to 50 grams per day, your ketone levels will dramatically increase and your blood sugar will drop.
After a day or two of this feasting, you then cycle back into nutritional ketosis (the “fasting” stage) for the remainder of the week.
My recent bestselling book, Fat for Fuel, explores these concepts in great detail and provides indispensable guidance for not only reaching ketosis but moving beyond into cyclical feasting and fasting to maintain your fat burning ability.
I suggest ordering your own copy of Fat for Fuel today, as there are far too many details and valuable tips for effective fat burning to present here.
Bottom line, if you want truly healthy mitochondria, a ketogenic diet isn’t optional. It’s a non-negotiable necessity.
The Race Against Time… How to Help Increase the Number of New Mitochondria in Your Aging Body
Researchers believe you may have about a 10-year window of opportunity to help save your mitochondria, from the time they first become damaged. Early changes in mitochondrial function may be reversed if caught early, and before the damage becomes permanent.
Aside from following a ketogenic or cyclical ketogenic diet, what else can you do to help protect the mitochondria you do have? And how can you help stimulate mitochondrial biogenesis or the growth of new mitochondria?
Exercise. Studies show that the mitochondrial DNA in muscle declines as you grow older. Regular, high-intensity exercise and maintaining a healthy weight may have a positive influence on mitochondrial health and life span.
Moving throughout your day – and avoiding prolonged sitting – are both important for your mitochondria. Any time your body experiences a greater energy need (as with exercise), it creates new mitochondria.
Exercise also helps stimulate mitophagy, or the removal of damaged mitochondria so they don’t accumulate in your cells.
Avoid environmental toxins. Glyphosate, the active ingredient in the herbicide Roundup, prevents the uptake of manganese and zinc, important minerals for protecting your mitochondria from oxidative damage.
The Roundup formula also makes your mitochondrial membranes more permeable, allowing more glyphosate to enter. And that, in turn, interferes with energy production.
Certain nutrients. A number of nutrients support mitochondrial function:
Ubiquinol (or CoQ10) – One of the most important antioxidants for protecting mitochondrial DNA, but levels decline rapidly with age
Magnesium – Helps increase the efficiency of your mitochondria to repair damage and produce ATP (energy)
Animal-based omega-3 fatty acids – Positively alter mitochondrial membrane structure and improve mitochondrial dysfunction in brain aging
All B vitamins (including thiamin, riboflavin, and B6) – Required as coenzymes for enzymes essential for cellular and mitochondrial function
Berberine – Supports mitochondrial health by activating AMPK which helps regulate energy homeostasis*
PQQ (Pyrroloquinoline quinone) – Helps protect mitochondria from oxidative damage and it stimulates the growth of new mitochondria*
There’s a good chance Tr haven’t heard much about Berberine or PQQ, especially as they relate to your mitochondria. However, the latest research shows both are important for mitochondrial health as they play critical roles in up-regulating and down-regulating important biochemical pathways.
Let me tell you more…
Berberine: One of the Few Compounds in Nature Known to Activate Your Metabolic Switch and Help Protect Your Brain Cells
Berberine is a yellow-colored alkaloid compound found in a number of plants: European barberry, goldenseal, Amur cork tree, Oregon grape, goldthread, tree turmeric, and phellodendron.
Originally isolated from traditional Chinese herbs, Eastern practitioners have known about berberine’s many potential benefits for centuries.
But it’s the most recent research that really has people excited about berberine for overall health and mitochondrial health.
There are about 2,800 berberine studies listed on PubMed and over a third of them are from the last 5-7 years!
So why all the excitement over a yellow-colored compound?
It has much to do with a vital enzyme inside your cells – adenosine monophosphate-activated protein kinase, or AMPK. Regarded as your metabolic master switch, AMPK plays a crucial role in regulating your metabolism.*
Researchers have discovered that berberine activates AMPK, which helps:
Regulate biological activities that promote normal balances of energy, lipids, and glucose*
Coordinate your body’s response to stressors*
Support cellular repair and maintenance*
And here’s something else you need to know about this alkaloid compound….
Berberine and Ketogenic Diets: A Match Made in Heaven?
Ketogenic diets provide profound protective benefits for your nerve and brain cells, but researchers are just now learning why…
The latest research on rats shows that the ketone bodies made by your liver during nutritional ketosis and fasting initiate three actions in your neurons, or nerve cells:
Increase levels hypoxia-inducible factor-1α, or HIF-1α
Activate Sirtuin 1, or Sirt1
Decrease mTORC1 activity
Together, these three actions help turn on what’s known as neuronal macroautophagy, or the purging of defective mitochondria from your cells.
Because berberine activates AMPK, as well as the activator for Sirt1, it helps boost autophagy in your cells. This, in turn, enhances the positive benefits from a ketogenic diet!
Studies also suggest that mitochondria are an important target of berberine.
While berberine’s role in cell health is still being closely studied, researchers do know that mitochondria selectively seek out and store berberine.
Because berberine is known to be involved in apoptosis, or normal programmed cell death, this potential advantage could play an important role in promoting healthy normal cell growth and development!*
Berberine Mimics the Effects of Exercise, Dieting, and Weight Loss!*
When AMPK is activated in your cells, an interesting cascade of events occurs. AMPK produces benefits similar to exercising, dieting, and weight loss!
While I certainly don’t recommend using berberine as a replacement for exercise or a healthy diet, research clearly shows it holds value for:
Slowing the release of free fatty acids to help prevent harmful fat deposits*
Promoting insulin, leptin, and adiponectin function for a healthy metabolism*
Supporting healthy blood sugar levels already in the normal range*
Promoting healthy insulin sensitivity*
Promoting healthy gut microflora*
Supporting healthy lipid metabolism*
Stimulating the release of nitric oxide for healthy blood flow*
Researchers have found that while berberine activates the enzyme AMPK, it inhibits what’s known as PTP1B activity. That action provides important support for healthy normal blood sugar levels.*
In one study, obese adults took 500 mg of berberine three times daily for 12 weeks study subjects saw a 23 percent decrease in triglycerides and a 12.2 percent drop in cholesterol levels.*
Berberine also plays an important role in promoting brown fat activity and boosting fat burning in your mitochondria.* Brown fat is a mitochondria-loaded, heat-generating type of fat that burns energy instead of storing it.
A study with mice showed berberine increased the expenditure of energy, and specifically enhanced brown adipose tissue (BAT) activity in mice who were obese.*
If you have a couple or a few extra inches to spare, especially stubborn belly fat, increasing the burning of brown fat may be a desirable side benefit of berberine!
Isolated in Interstellar Stardust by NASA, PQQ May Be a Breakthrough for Mitochondrial Health*
Every now and then a nutrient comes along that generates a great deal of excitement in the research community.
As we’ve already seen, Berberine is one of those nutrients. PQQ, or pyrroloquinoline quinone, is another…
First identified as an enzyme cofactor in 1979 in microorganisms, PQQ has also been potentially detected in interstellar samples collected by NASA’s probe Stardust.
Here’s the significance of this finding:
PQQ has been around for a long, long time
PQQ is ubiquitous and humans and animals have been widely exposed to it
PQQ is involved in many critical biological functions
Its potential benefits are impressive, and its involvement in important cell signaling pathways indicate PQQ is an especially crucial nutrient for your mitochondria.*
Researchers have found that PQQ works exceptionally well with CoQ10 or ubiquinol, the reduced form of CoQ10. Ubiquinol and CoQ10 optimize mitochondrial function and help protects them from free radical and ROS damage, while PQQ, also a coenzyme, triggers the creation of new mitochondria.*
How PQQ Helps Create New Mitochondria in Aging Cells
Even though PQQ is bacterial in nature, your body and your gut microbiome do not have the ability to produce it naturally. That suggests PQQ may be an essential micronutrient.
In 2010, a team of researchers at the University of California discovered that PQQ has the unusual ability to activate not one, but three cell signaling pathways:
PGC-1 – stimulates genes that enhance mitochondrial and cellular respiration, growth, and reproduction*
CREB – interacts with histones that protect and repair cellular DNA while stimulating the growth of new mitochondria*
DJ-1 – like PGC-1 and CREB, DJ-1 supports cell function and survival, especially in the brain, and helps guard against cell death from antioxidant stress*
A 2012 research advance took a closer look and found that PQQ activates genes that induce mitochondrial biogenesis, or the spontaneous formation of new mitochondria in aging cells.*
Scientists also observed that when cells are deficient in PQQ, a significant number of genes can be profoundly affected.
A total of 438 genes to be exact…
Most impacted are those genes involved in cellular stress, cell signaling, metabolite transfer, and the biogenesis of new mitochondria.*
However, the researchers were able to reverse the negative effects by providing PQQ supplementation.
The importance of PQQ for the growth of new mitochondria was further confirmed by a recent mouse study. Mice deficient in PQQ were shown to have a 30-40 percent reduction in numbers of mitochondria, compared to mice who were supplemented with PQQ.
Up to 5,000 Times More Efficient Than Vitamin C at Reducing Oxidation
As we’ve seen, damage to mitochondrial DNA from the massive assault of free radicals and reactive oxygen species is a root cause of aging.
That makes antioxidants especially valuable for protecting your mitochondria. But some antioxidants are clearly more effective than others…
Research shows that PQQ is 30 to 5,000 times more efficient at reducing oxidation than other common antioxidants such as vitamin C.
This 2010 study contrasted the protective effects of PQQ with other antioxidant compounds. Not only were those differences great, but the difference in the amounts needed of various compounds to effectively increase the number of mitochondria and mitochondrial functioning was especially striking.
While it took millimoles of other compounds to achieve cellular protection, the dietary concentrations of PQQ required could be measured in nanomoles!
Considering that one millimole equalsone million nanomoles, that’s a profound difference in concentrations!
PQQ is found in human milk and in small amounts in many common foods, including kiwi, natto, tofu, green tea, and green peppers.
Researchers now believe higher doses of PQQ – higher than what’s found in foods – may be valuable for:
Supporting neurological function*
Supporting immune health*
Supporting cardiovascular health*
Enhancing antioxidant status in tissues and cells*
And its effects on cerebral function, memory, and metabolism have been studied as well…
Studies Confirm PQQ’s Potential Effects on Brain Function, Memory, Stress, and Sleep
Several human studies support claims about PQQ’s effects on cognitive health and brain function, as well as stress and sleep quality:
PQQ helps brain cells function more efficiently.* PQQ has been shown to facilitate nerve regeneration and enhance nerve growth factor.* And it increases the number and efficiency of mitochondria.*
PQQ improves cerebral function.* The effect of PQQ on cerebral function and anti-stress activity was tested in 71 human subjects over a 12-week period using 20 mg of PQQ and 20 mg of PQQ with 100 mg of CoQ10. Both groups showed improvements in high-level cerebral functions, including attention and information discrimination.*
PQQ with or without CoQ10 improves memory.* This double-blind study among adults aged 50-70 evaluate PQQ with CoQ10 (or ubiquinol) and PQQ alone for 24 weeks. Both groups experienced immediate improvement with memory and other brain functions like spatial awareness.*
PQQ helps counteract the effects of stress and improves sleep quality.* A group of 17 adults took a daily dose of 20 mg of PQQ for 8 weeks. All six measures of vigor, fatigue, tension, mood, anger-hostility, and confusion improved significantly.* Quality of life and sleep also improved significantly.*
PQQ, like Berberine, clearly plays an important role in many aspects of health and daily life.