Parkinson’s – Another Look – Lawrence Broxmeyer, MD

Posted on November 22, 2016 by Mimi Castellanos

the book is here:

https://www.evernote.com/shard/s99/sh/542c807a-9a4d-4e84-9991-0ad5cf5bbae2/2c04119e814ec6f04231bd14265f3c57

Medical Hypotheses (2002) 59(4), 373–377 a 2002 Elsevier Science Ltd. All rights reserved.

doi: 10.1016/S0306-9877(02)00188-3, available online at http://www.idealibrary.com

Parkinson’s: another look

L. Broxmeyer

Med-America Research, Whitestone, New York, USA

Summary Recent studies in the Parkinson’s literature have cited a tuberculosis-like germ called Nocardia as being responsible for Parkinson’s disease. Kohbata seemingly cemented a relationship between Nocardia and Parkinson’s by finding serologic evidence in 20 of 20 Parkinson’s patients, acknowledging that blood tests for Nocardia and the mycobacteria such as tuberculosis often cross-react, as they belong to the same order of bacteria, the Actinomycetales. Besides this difficulty in differentiation, a well-used medical school textbook of microbiology, Atlas, points out that even among experts, different observers may classify the same strain of bacteria as Nocardia or Mycobacterium tuberculosis. Parkinson’s: another look is a theoretical article which presents compelling, well-documented evidence for an infectious cause for Parkinson’s disease on historical, epidemiological, pharmacologic, microbiological, and biochemical levels. a 2002 Elsevier Science Ltd. All rights reserved.

BACKGROUND

Recent studies in the Parkinson’s literature have cited a tuberculosis-like germ called Nocardia as being respon- sible for Parkinson’s disease (1,2) on several occasions confirmed serologically in the blood. Kohbata seemingly cemented a relationship between Nocardia and Parkin- son’s by finding serologic evidence in 20 of 20 Parkin- son’s patients, acknowledging that blood tests for the Nocardia and the Mycobacteia such as tuberculosis often cross-react, as they belong to the same order – Actino- mycetales (3). Besides this difficulty in differentiation, a well-used medical school text of microbiology points out that even among experts, different observers may clas- sify the same strain as Nocardia or Mycobacteium tuberculosis (4). To add to existing difficulties, both or- ganism’s can be acid-fast, a property long used to iden- tify M. tuberculosis. Atlas also mentions still another Actinomycetales/corynebacteria as equally hard to pick out from the others. Diptheria is a corynebacteia which Martyn found linked to Parkinson’s (5). But even before this, diptheria’s role in PD peppered the Index Medicus

Received 21 May 2001 Accepted 31 October 2001

Correspondence to: Lawrence Broxmeyer MD, Med-America Research, 148-14A Eleventh Avenue, Whitestone, New York 11357, USA.

for decades. By 1994 Gao proved through the use of mycobacterial heat shock proteins against the blood of two Parkinson’s patients that mycobacteria were some- how linked to Parkinson’s (6). All of this has occurred in a setting in which not only do twin studies cast a doubtful aura regarding Parkinson’s as hereditary (7,8) but other seemingly environmental causes are so diverse as to boggle the mind, unless it is recognized that many of these factors affect the disposition of the germ that actually causes Parkinson’s to multiply, thrive and at- tack the dopaminergic nerve centers in the brain.

By 1934, Burn of Yale had identified a Gram-positive bacillus from the bloodstream of three infants that died from Parkinson causing Von Economo’s encephalitis (9). This pathogen, in its sluggish motility and resemblance to Listeria monocytogenes, bore an eerie resemblance to an organism which with advanced stains was found to be acid-fast by a network of post-World War II female M.D.’s and PhD’s (10), some of whom consistently found the germ in Wilson’s disease, a primary cause of Parkinson’s in the young (11). It had evolved as a cross between the mycobacteria and the nocardia as a result of viral phage transfer between the two species (10,12). Furthermore, the important Parkinson’s DATATOP study (13) unwittingly settled upon an agent from a class originally designed to cure tuberculosis, an MAO in- hibitor called Deprenyl (14). And recently Fuente-Agu- ado (15), Kurasawa (16), Mital and Sarkari (17), Otaki

373

374 Broxmeyer

(18) and Solanki (19) all cured symptomatic Parkinson’s using anti-tuberculous medications.

HISTORICAL AND OTHER PARALLELS

Parkinson’s and tuberculosis share many common threads. Both came into force and were linked with the great Industrial Revolution. The substantia nigra was established as important to Parkinson’s through a tu- berculous attack on an autopsied patient (20). Both share a common preferential site of attack, the convexity or underside of the brain were the substantia and basal ganglia lie. Parkinson’s last great epidemic, Von Eco- nomo’s Encephalitis was, according to Hall, almost in- distinguishable from T.B. (21). And Duvoisin all but ruled out any of the suspected viruses implicated at the time (22). Even in AIDS, often associated with Parkin- son’s, mycobacteria such as tuberculosis have been re- ported as the most common central nervous pathogen in HIV-infected people (23). Many of the patients with both Parkinson’s and T.B. share the common denominator of a chronic wasting disease, a cachexic eating away of the flesh. Finally both are primarily diseases of older people with a male preference.

EPIDEMIOLOGICAL CONSIDERATIONS

Guam sits in the southernmost Marianas, within the Asian Pacific Rim. Regions in the world where T.B. is most prevalent lie within that rim. It soon became rec- ognized that Guam had a relatively high number of neurodegenerative diseases in its midst – among them a Parkinson-dementia complex which melded classical Parkinson’s often preceded by memory impairment (24). Parkinson’s and ALS alone affect 10% of Guam’s natives. This, in America would be equal to approximately 27 million Americans affected, a nightmarish scenario. Leprosy was once common in the Mariana’s, but now is rare (25). To this day, there is no explanation as to why leprosy disappeared from the Mariana’s, but T.B. men- ingitis, common, remained.

At first, investigators thought it was only Guam’s in- digenous natives, called the Chamorros that were af- fected by these neurodegenerative diseases. But since Magellan’s Spanish claim to and discovery of the Mari- ana’s, the Island’s demographics where changing, rap- idly. By the 18th century, Filipino immigration created a situation where approximately 1 out of 5 Chamorros were direct descendants from Filipino–Chamorro un- ions. Soon it was discerned that after a mean lapse of two decades, Filipino’s were also contracting PD–Dementia on Guam. Or, were they importing it from the Philip- pines (26)? The question seemed impenetrable to Garr- uto until further epidemiologic studies were done back

in the Philippines. A recent study published in JAMAlists Filipino immigrants to the U.S. as having the highest case rates for tuberculosis among foreign-born persons, second only to immigrants from Mexico (27). Mulder acknowledged that T.B. is a leading cause of death on Guam and that T.B. meningitis was not infrequently seen in its hospitals (28).

Lessell’s study on the febrile seizures that accompany neurodegenerative disease concluded that the over- whelming majority of these occurred in the setting of upper respiratory tract infection (29). This does not support known viruses carried by insects. Hirano and Malamud’s 17 post-mortems on Parkinson–Dementia Complex showed two that presented with pulmonary tuberculosis (30), while several others had ‘pneumonia’ which in turn could have been caused by cryptic tu- bercular disease. But even in this study of general pathologic findings, most of the 17 cases presented with neuropathic changes duplicated in the literature of tu- berculous meningoencephalitis.

SMOKE SCREENS

Since James Parkinson wrote Essays on the Shaking Palsy, a mind-boggling number of causes and ‘risk factors’: infectious, pharmacologic, industrial and degenerative, have been implicated to cause the disease he first doc- umented. In few cases has doctor/medical researcher James Young’s warning been more applicable:

Sixty years ago, to claim that the specific disease tu- berculosis of the lungs had a multiplicity of direct causes was in keeping with the knowledge of the period. Thus it was believed that the inflammation of a bronchitis, the irritation of the inhaled frag- ments of stone with which this mason worked, etc. were each one a ‘direct’ cause of pulmonary tu- berculosis, and that there were many other causes as well – for example heredity, unhealthy environ- ment, etc. Time has shown that the greatly different direct irritants and the other indirect agencies oper- ate in one common way – by increasing cell and tis- sue susceptibility to the one common factor, the tubercle bacillus. In many other cases the history of medical progress has shown that, where several causes have been advanced to account for a dis- ease, these have proved to be nothing more than factors preceding, and predisposing to, the single common agent (31).

James Young, 1924

As Jancovic relates, if Parkinson’s was from a genetic cause, it would cluster primarily within at-risk gene lin- eage, but this, in general, has not been the case (32). In the meantime studies of twins, in which twins from a

Medical Hypotheses (2002) 59(4), 373–377

a 2002 Elsevier Science Ltd. All rights reserved.

single egg show no higher incidence of Parkinson’s than those from two eggs, also argue against a genetic basis for Parkinson’s (8).

Furthermore, most of the single-gene mutations found more commonly in Parkinson’s code for meta- bolic enzymes. But Merrill, Geier and Petricciani induced human cells to initiate enzyme synthesis through in- fectious (bacterial) gene change (33). This validated Morse and Lederberg’s earlier work which showed that the genetic code is universal and that genetic changes in human cells could come about by bacteria and their phage viruses within.

Inside disease-causing bacteria are viruses called ‘phages’. It has long been known that not only do bac- teria such as mycobacteria get infected with these phage viruses, but that there is an invisible war, called ‘lysog- eny’ going on, in which bacteria use phages as viral weapons. Lysogeny is where one colony of bacteria sets out to destroy another by launching its tadpole-shaped phages towards its victim. If phages do not kill, they can genetically alter, creating new and dangerous germs for mankind to cope with. Furthermore, Mankiewicz, col- laborating with Jackson established that phages inside mycobacteria such as tuberculosis could induce cyto- pathogenic changes in healthy mammalian tissue (12). Meanwhile, Lwoff and early phage workers showed how the phages inside Mankiewicz’s mycobacteria could be activated by a host of chemical and other agents (34), some of them pesticide-like, explaining how the prolif- eration of different agents felt to cause Parkinson’s could have occurred – by chasing phages with a cytopatho- genic capability for human target tissue out of an exist- ing bacterial infection.

In so far as those who would link the well-known risk factor of rural living to increased chemical exposure as a cause, Jancovic notes this could just as easily reflect exposure to an infectious agent (32). The Actinomyce- tales including the nocardia and mycobacteria are soil born worldwide and include Mycobacteria kansii.

Gorell documents that prolonged occupational ex- posure to copper, manganese and iron are all associated with Parkinson’s (35). But David, an expert on myco- bacteria, points out that mycobacterial cell mass can be greatly increased in the lab by adding any of these agents to existing culture medium (36).

On a biochemical level, oxidative stress has been mentioned as contributing to Parkinson’s. The substan- tia nigra is under triple jeopardy from oxidant stress injury. In the body tyrosine is first converted to dop- amine, itself highly toxic to catecholamine cells (37). Dopamine in turn is metabolized to hydrogen peroxide and free radical byproducts, which again can damage cell components of substantia (38). In addition, neuro- melanin, found in the substantia’s pigmented neurons,

contains large amounts of iron (39) which as has been mentioned is a significant growth factor for mycobacte- ria (36). Dopamine-derived hydrogen peroxide reacts with this iron, generating extremely neurotoxic free hydroxyl radicals. In 1991, Ben-Shacher and Youdin, by intranigral iron injections induced Parkinson’s in rats (40).

Just how much of what’s been documented in PD is secondary to mycobacterial intermediate metabolism is open to question. But mycobacteria are strict aerobes and oxygen must be available as the final electron ac- ceptor. Three distinct respiratory chains have been de- scribed, one of which leads to the formation of hydrogen peroxide. The disposal of accumulated hydrogen per- oxide is then accomplished by two iron–porphyrin en- zymes, catalase and peroxidase, which occur in all mycobacteria and the products of which release their own free oxygen radicals (36).

In addition, mycobacteria synthesize their own tyro- sine, precursor to dopamine in humans (36), and a pos- sible source of ‘oxidant stress overload’ as individual generations of mycobacteria are replaced during an en- suing infection.

Also, how much dead mycobacteria, who’s lipid content can amount to 40% of their dry weight (41), account for the higher levels of lipid peroxidation seen in the Parkinson’s substantia (42), is open to interpretation, as is whether the increased level of iron found in Par- kinson’s substantia (43) couldn’t at least be in part due to mycobacterial iron porphyrin release.

Pathologically in Parkinson’s there is an accumula- tion of melanin-containing nerve cells brain the in stem, chiefly in the substantia nigra and the locus coeruleus (44). Melanin may be formed biologically in vitro by oxidation of tyrosine or tryptophan, both of which are aromatic amino acids manufactured by the mycobacte- ria (36).

CONCLUSION

It might have been coincidental that both Mycobacteria tuberculosis and Parkinson’s came in to force and were linked with the great Industrial Revolution. Or fortuitous that Blocq and Marinesco established through tubercu- loma attack that the substantia was important to Par- kinson’s (20). It could be considered incidental that the preferential site of attack of tuberculosis meningoen- cephalitis is the convexity of the brain, where it covers the substantia, the basal ganglia and has ready access to the cranial nerves. Perhaps even coincidental that Von Economo’s encephalitis, which caused Parkinson’s reg- ularly, was, according to Hall and the ARNMD almost indistinguishable from CNS T.B. (21,45). It might be considered a fluke that Deprenyl (Eldopril) a Parkinson’s

a 2002 Elsevier Science Ltd. All rights reserved.

Medical Hypotheses (2002) 59(4), 373–377

Parkinson’s: another look 375

376 Broxmeyer

mainstay, comes from a class, the MAO inhibitors orig- inally designed to cure tuberculosis (14). Or circum- stantial that clinical and epidemiologic studies have peppered Parkinson’s literature for decades linking tu- berculosis-like germs: including nocardia, corynebacte- ria (diptheria) and the mycobacteria – not only easily confused by seasoned bacteriologists (4) but which also cross-react under serological identification (3). It might be considered adventitious that Burn isolated a germ (9) with an eerie resemblance to Jackson and Livingston’s (10, 11) mycobacteria/nocardia cross in three Von Eco- nomo’s infants at autopsy; or that Jackson found acid- fast forms in Burn’s bacillus that she implicated as causing Wilson’s disease (11), dominant cause of Par- kinson’s in the young. It might be considered insignifi- cant that tuberculosis-like Nocardia has a specific affinity for substantia nigral neurons (1) and that the most convincing Parkinson’s animal model to date happened when Beaman injected nocardia into mice (2). It might seem random that Kohbata & Shimokawa ce- mented a relationship by blood serology between no- cardia and mycobacteria in 20 of 20 Parkinson’s patients (3) or that Gao linked Parkinson’s to mycobacteria in blood through diagnostic heat shock proteins (6). It could be considered anecdotal that Mital and Sarkari (17), Otaki (18), Fuente-Aguado (15), Solanki and Ku- rasawa (19) all independently cured Parkinson’s with anti-tuberculosis therapy. It could be called inconse- quential that in AIDS-related Parkinson’s, sometimes listed as the most common cause of infectious Parkin- son’s, that Berenguer reported mycobacteria as the most common CNS pathogen in HIV infected people (23). It could be considered coincidental that Guam, where T.B. meningitis runs rampant, hosts an epidemic number of neurologic disorders, including Parkinson’s–Dementia (24). It might seem that there is a lack of essential con- nection between the post-traumatic Parkinson’s, say of an ex-boxer, and the fact that such trauma could also have caused a long-standing infection, such as tubercles in the brain, planted even decades before, to discharge bacilli into the meningeal spaces (46), reactivating a long quiescent disease from one punch too many. And it might seem unrelated that occupational exposure to copper, manganese and iron(35) are all not only associ- ated with parkinsonism but the very substances which act as mycobacterial growth factors in the laboratory (36).

And it might seem chance that the triple jeopardy of oxidative stress under which the substantia sits, namely catecholamine toxic dopamine, derived from tyrosine; hydrogen peroxide and free radical byproducts: all of which can damage the substantia (38) are also manu- factured by mycobacterial intermediary metabolism and cell-respiration (36).

It might be considered random that many Parkin- son’s victims show the same cachexic wasting away that has long typified consumption – or that the do- paminergic neuron loss McGear found as an active Parkinson’s process, even after death (47), is just the sort of chronic process that so characterizes a disease like tuberculosis, which often begins in youth or childhood.

It could be considered incidental that tuberculosis and Parkinson’s are presently considered diseases of the older population with more men than woman affected.

But in the end, and taken together, there are just too many coincidences in an ever-growing list to just casu- ally dismiss.

In conclusion, the preponderance of convincing evi- dence, as we near the bicentennial of James Parkinson’s original Essay points to a chronic infectious cause, not viral and most likely of the family Actinomycetales – ei- ther mycobacterial or a tuberculosis-like mycobacterial/ nocardial cross. Clinical trials await.

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Medical Hypotheses (2002) 59(4), 373–377

 

 

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The Science of Bravo – Bravo Probiotic Publications

Posted on August 23, 2016 by Mimi Castellanos

Bravo Probiotic Publications

  • The Super Probiotic. Health Hunters, Newsletter. 27, 1, 2013.
  • Macrophages of the mucosa-associated lymphoid tissue (MALT) as key elements of the immune response to vitamin D binding protein-macrophage activating factor. S. Pacini,

et al. Italian Journal of Anatomy and Embriology, 2014.

  • Glycosylated oleic acid/vitamin D-binding protein suppresses Her2 oncogene expression in human breast cancer. M. Ruggiero, et al. Anticancer Research, Sithonia, Grecia,

6-10 Ottobre 2014.

  • Clinical experience of immunotherapy based on oleic acid bound to glycosylated vitamin D- binding protein in localised and metastatic adenocarcinoma of the pancreas.

L. Thyer, et al. Anticancer Research, Sithonia, Grecia, 6-10 Ottobre 2014.

  • Focussed transcranial ultarsounds: application to the delivery of glycosylated oleic acid/vitamin D-binding protein to brain tumours and metastases.

J.J.V. Branca, et al. Anticancer Research, Sithonia, Grecia, 6-10 Ottobre 2014.

  • Clinical experience of cancer immunotherapy integrated with oleic acid complexed with de- glycosylated vitamin D binding protein. E.Ward, et al. American Journal of

Immunology 10 (1): 23-32, 2014.

  • Clinical experience of renal carcinoma immunotherapy with oleic acid complexed with de- glycosylated vitamin D binding protein. S. Aterini, et al. 55° Congresso Nazionale Società Italiana Nefrologia. Catania, 8-11 Ottobre 2014.
  • Oleic acid, deglycosylated vitamin D-binding protein, nitric oxide: a molecular triad made lethal to cancer. M. Ruggiero, et al.Anticancer Research, 34: 3569-3578, 2014.
  • Gc-protein-derived macrophage activating factor (GcMAF) induces ERBB2 shift in human breast cancer. M. Ruggiero, et al. Società Italiana di Anatomia e Istologia,

Ancona, Settembre 2014.

  • Intra-tumoural nitric oxide release by macrophages activated by Gc-protein-derived macrophage activating factor (GcMAF). M. Ruggiero, et al. Società Italiana di Anatomia

e Istologia, Ancona, Settembre 2014.

  • Clinical experience of integrative immunotherapy centred on olei acid complexed with de- glycosylated vitamin D binding protein. E. Ward, et al. IX National Conference of

the Italian Society of Immunology, Clinical Immunology and Allergology. Firenze, 28-31 Maggio 2014.

  • Increased splenic blood flow following macrophage activation by oleic acid complexed with de-glycosylated vitamin D binding protein. E.Ward, et al. IX National Conference of

the Italian Society of Immunology, Clinical Immunology and Allergology. Firenze, 28-31

Maggio 2014.

– Effects of Pre-Surgical vitamin D supplementation and ketogenic diet in a patient with     recurrent breast cancer. J.J.V. Branca, et al. Anticancer Research, 35: 5525-5532, 2015.

– El ser humano tiene cuatro cerebros. Marco Ruggiero. Discovery Salud N. 194, Junio 2016.

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The Science of Bravo – Oleic Acid, Deglycosylated Vitamin D-Binding Protein, Nitric Oxide: A Molecular Triad Made Lethal to Cancer

Posted on August 23, 2016 by Mimi Castellanos

Oleic Acid, Deglycosylated Vitamin D-Binding Protein, Nitric Oxide: A Molecular Triad Made Lethal to Cancer

Abstract. Background: Oleic Acid (OA) has been shown to have anticancer properties mediated by interaction with proteins such as α-lactalbumin and lactoferrins. Therefore, we synthesized complexes of OA and Gc protein-derived macrophage activating factor (GcMAF) that inhibits per se cancer cell proliferation and metastatic potential. We hypothesised that OA-GcMAF complexes could exploit the anticancer properties of both OA and GcMAF in a synergistic manner. We postulated that the stimulating effects of GcMAF on macrophages might lead to release of nitric oxide (NO). Patients and Methods: Patients with advanced cancer were treated at the Immuno Biotech Treatment Centre with OA- GcMAF-based integrative immunotherapy in combination with a low-carbohydrate, high-protein diet, fermented milk products containing naturally-produced GcMAF, Vitamin D3, omega-3 fatty acids and low-dose acetylsalicylic acid. Results: Measuring the tumour by ultrasonographic techniques, we observed a decrease of tumour volume of about 25%. Conclusion: These observations demonstrate that OA, GcMAF and NO can be properly combined and specifically delivered to advanced cancer patients with significant effects on immune system stimulation and tumour volume reduction avoiding harmful side-effects.

It is well-assessed that Oleic Acid (OA), a recognised fundamental component of healthy diets (1), shows anticancer properties (2) that contribute to the increase in

longevity and reduced risk of mortality and morbidity associated with its consumption (1). Although the precise molecular mechanism responsible for its anticancer properties is not completely understood (2), it appears that OA is involved in intracellular calcium signalling associated with the induction of cancer cell apoptosis.

It has been proposed that the anticancer effects of OA are mediated by its interaction with proteins highly represented in biological fluids such as α-lactalbumin and lactoferrins. These proteins bind OA to form OA-protein complexes which exhibit highly selective anti-tumour activity in vitro and in vivo (3). Soon after their identification, these complexes were labelled as HAMLET an acronym that stands for “human α-lactalbumin made lethal to tumour cells”, even though further studies demonstrated that α- lactalbumin is not the sole protein forming such complexes. Thus, other proteins, forming complexes with OA, exhibit identical anticancer properties (4). It is now accepted that these OA-protein complexes destroy tumour cells with high selectivity and with no evidence of toxicity for normal tissues, a key feature in the quest for anticancer treatments devoid of toxic side effects.

Study of the structural characteristics of such anticancer OA-protein complexes demonstrated that a common molecular feature is the tendency toward OA-induced protein oligomerization. Since OA-induced oligomerization has been reported for a number of proteins in addition to those initially identified in HAMLET, it was hypothesised that this phenomenon may be inherent to many proteins (5).

Some of the proteins forming OA-protein anticancer complexes such as α-lactalbumin and lactoferrins are highly represented in milk. These compounds are known to exert powerful stimulatory effects on the immune system (6). These findings provide additional acceptance to the hypothesis that the immune system is directly involved in the overall anticancer effects of OA-protein complexes.

The Article is here: Anticancer Res lavoro

 

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Science of Bravo – Effects of Pre-surgical Vitamin D Supplementation and Ketogenic Diet in a Patient with Recurrent Breast Cancer

Posted on August 23, 2016 by Mimi Castellanos

Effects of Pre-surgical Vitamin D Supplementation and Ketogenic Diet in a Patient with Recurrent Breast Cancer

Abstract. Background: A woman, mother of one at the age of 19 years, was diagnosed with mammary adenocarcinoma in the right breast in 1985 at the age of 37 years. The patient underwent surgery (quadrantectomy), lymphadenectomy and radiotherapy. In 1999, an adenocarcinoma was diagnosed in the left breast, followed by adequate resection, radiotherapy and anti-oestrogen receptor treatment for 6 years. In March 2014, an infiltrating adenocarcinoma was diagnosed in the remaining part of the right breast that had been operated on and irradiated in 1985. Case Report: The pre-surgical biopsy, showed weak positivity for progesterone receptor (PgR) (<1%), high positivity for oestrogen receptor (ER) (90%), high positivity for human epidermal growth factor receptor (HER2) (>10%, score 2+), and high positivity for the nuclear protein Ki67 (30%). In the three weeks between diagnosis and operation, when no other treatment had been planned, the patient decided to self-administer high doses of oral vitamin D3 (10,000 IU/day), and to follow a strict ketogenic diet. Results: Following right mastectomy, analysis of the surgical specimen showed no positivity for HER2 expression (negative, score 0), and significant increase in positivity of PgR (20%). Positivity for ER and Ki67 were unaltered. Conclusion: This observation indicates that a combination of high-dose vitamin D3 and ketogenic diet leads to changes in some biological markers of breast cancer, i.e. negativization of HER2 expression and increased expression of PgR.

Complete Article Here: Anticancer Res KD-2-1

 

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The Science of Bravo – CLINICAL EXPERIENCE OF CANCER IMMUNOTHERAPY INTEGRATED WITH OLEIC ACID COMPLEXED WITH DE-GLYCOSYLATED VITAMIN D BINDING PROTEIN

Posted on August 23, 2016 by Mimi Castellanos

CLINICAL EXPERIENCE OF CANCER IMMUNOTHERAPY INTEGRATED WITH OLEIC ACID COMPLEXED WITH DE-GLYCOSYLATED VITAMIN D BINDING PROTEIN

Received 2014-02-26; Revised 2014-03-07; Accepted 2014-03-8

ABSTRACT

Proteins highly represented in milk such as α-lactalbumin and lactoferrin bind Oleic Acid (OA) to form complexes with selective anti-tumor activity. A protein present in milk, colostrum and blood, vitamin D binding protein is the precursor of a potent Macrophage Activating Factor (GcMAF) and in analogy with other OA-protein complexes, we proposed that OA-GcMAF could demonstrate a greater immunotherapeutic activity than that of GcMAF alone. We describe a preliminary experience treating patients with advanced cancers, often labelled as “incurable” with an integrative immunotherapy centred on OA-GcMAF. Patients with advanced cancer were treated at the Immuno Biotech Treatment Centre with OA-GcMAF-based integrative immunotherapy in combination with a very low carbohydrate, high protein diet, fermented milk products containing naturally produced GcMAF, vitamin D3 and low-dose acetylsalicylic acid. When the primary tumor or a metastasis could be measured by ultrasonographic techniques, we observed, on average, a decrease of tumor volume of approximately 25% in a week. We also observed a consistent increase in splenic blood flow that was interpreted in the context of generalised immune system activation and allowed to assess the degree of responsiveness of the individual patient. The results reported here are consistent with the results previously described in the experimental animal harbouring a human hepatocellular carcinoma as well as with the results reported for neoadjuvant chemotherapy. OA-protein complexes are bound to play a leading role in cancer therapy thanks to selectivity of antitumoral effects, absence of any side effects, safety and oral availability. We hypothesise that OA-GcMAF, combines the known anticancer

Article as PDF Here :  Am J Immunol

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Dr. Budwig’s protocol

Posted on August 18, 2016 by Mimi Castellanos

Healing Intention:  To charge the body’s batteries so that its immune system functions properly, removing parasitic colonies and restoring electrical and nutritional balance.

A clear, happy and balanced environment and activity with low stress will allow health to emerge through happy energized cell division.  Dead batteries will not sustain the body!

Dr Ruggiero recommends his product called Rerum.  Here, you can extract the elements of Rerum to see how it works for you and then possibly moving to using Rerum as you feel the need and see the benefit.  Rerum is Oleic Acid, Sulfer, and Bravo is in its protocol.  We can substitute the Bravo for the cottage cheese or kefir which is used in the Budwig protocol and use our own very super fresh oils.  This is a wonderful upgrade combination of Ruggiero, Budwig, and Gerson for powerful intervention and interruption of any disease cycle.

You can have custom pressed fresh oils made especially for you and overnighted that same day on ice.  Have the most incredibly fresh oil possible without doing it yourself at BravoCoop.com. 🙂   Of course, you can press your own fresh oils for yourself.  check it out here.

Put on your study hat. . . . Let’s dive in .  . . Some info from the internet…

The basis of Dr. Budwig’s protocol is the ingestion of a special oil-protein mixture in the form of organic cold-pressed flaxseed oil plus cottage cheese (“quark” in Europe). When you blend together, cottage cheese and linseed (flaxseed) oil in your blender, the fat becomes water-soluble and thereby are immediately available for use by the body. This provides a necessary “spark plug” for cells to “breathe”,  optimally detoxify, and function.  This is specifically important when it comes to cell division and resisting microbial invasion.  You feed and water your plants.  Now you can feed, water, and oil your cells for optimal live and vitality.

Before you proceed to reading any further, please know not everybody reacts the same to this or any other treatment. In any healing diet or protocol one may undertake, please respect the amazing influence of the Mind, belief, emotions energetic and spiritual factors, on disease and healing.  If you have trouble with blood thinning or blood diseases, check out this video of precautions because oils can thin the blood. https://www.youtube.com/watch?v=Jso_wbpXirg

Dr. Budwig has literally pulled people back from death’s doorstep with her relatively easy-to-implement protocol; and doubtless, her powerful confidence-inducing personality. The “Budwig diet” is based on the critical importance of the right fatty acids plus sunlight (via D and K2), and the deleterious effect of the wrong fats. This regimen has been hailed by some as the best fundamental healing approach for many stricken with a cancer challenge.

Get a touch of overview and understanding about how important the recharging is here:

Treating Causes of Cancer and Not Symptoms

Why is the Budwig protocol so successful? It addresses the four main causes of cancer and most other chronic illnesses, which are:

  • Viruses and other harmful microbes (bacteria, viruses, fungus and parasites),
  • Toxins, (ie. Chemical toxins, as well as emotional shock and/or stress),
  • Inadequate cellular nutrition causing malfunction of major organs and a lack of adequate oxygen in the cells,
  • Weak or compromised Immune system.

    Method:  Healthy fats and sulfur balance through proper water/oil emulsification.  There is a way to make an oil like flax oil, able to be absorbed into our bodies through blending the oils and waters properly.  Here in the food we are doing it with a mixer but in the body as it stands, it is known as EXERCISE.  Remixing your healthy fats and waters and keeping the septic waters moving in your body.  You will want to move your body!

    Ingredients of this program:  Wholesome fats to clean and allow healthy cell division. Sulfur from the dairy and nutrition to access proper cell division. Vitamin D & K2 or sunshine and exercise, (Did I say that already?)

HOW TO INSTRUCTIONS FOR BUDWIG MIXTURE:

3 Main Ingredients:

Flax meal (1 TBS) –

  •                         Do not buy pre-ground flax seed as the flax seed goes rancid 15 mins
  •                         Brown or Golden whole Flaxseed is available and either will work.
  •                         Buy organic whenever possible to eliminate chemical contamination
  •                         Grind fresh each time in a blender or coffee grinder

Organic Cottage Cheese or Bravo GcMAF Yogurt (4 TBS)

  •                        Raw organic dairy (or best available) to be used to culture the Bravo
  •                        Use your particular current dose of Bravo when building for the 1st month
    •                          Use 1/2 the amount of bravo for flax oil measurement
    •                          USE 1/4 the amount of bravo for flax meal measurement
  •                        It’s okay to substitute other  cottage cheese to make more.
  •                        Less Bravo is more! Use the right amount for yourself to feel great.

Organic cold pressed Flax Seed Oil (2 TBS)

  •                        Watch the expiration date for the freshest available
  •                        Don’t use use Flavored, Lignum or Highest Lignum
  •                        Look in the refrigerated section of the grocery or health food store
  •                        Never off the shelf. Never capsule or flakes
  •                        Contact BravoCoop.com for freshly made, over-nighted custom blends

BLENDING:

Mixer: Mixing the ingredients is easy if you have a vitamix type blender, nutribullet, or you can use a coffee grinder and immersion blender.

Concept: The concept is to mix the fresh ingredients and not to have any standing oil.  It is mixed into a creamy quality where the oil is resolved.

Start with the flax seeds and grind dry seeds into a powder. Then add the other ingredients and continue to blend to a creamy quality where the oil has been absorbed.  This won’t take long and more mixing is not better.

If you wish to add nutrition such as tumeric, sprouts, a few green leaves, or a few pieces of fruit, they can be added.  Heavy foods or supplements should be taken at a separate time such as 1/2 hour before or after.

Make the mixture fresh each time and eat it immediately for best results

Here’s the link to one (YouTube) page showing how to combine the Flax Oil and Cottage Cheese in a video.
http://www.youtube.com/watch?v=RSoddp…

The above protocol should not be consumed with any other supplements, foods or oils at the same time. This should be a stand alone meal.

and here is an alternative http://youtu.be/RqP-0b2ilq4

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Heal yourself of Interstitial Cystitis

Posted on June 30, 2016 by Mimi Castellanos

Sorry for such a quick explanation.  You might not be able to do it yourself but these are notes to get you to me and more teaching…  mimi@bravocoop.com

funny you should mention not finding anyone to help the misery of Interstitial Cystitis.

I know what causes it and what to do about it.
I cured my mom’s and the  urologist confirmed and asked me to go into the research lab and teach them.
I don’t have time to explain right now, sorry.
I have a trillion things to do to make my flight tomorrow to do a trillion more things.
If you email me gently and keep me focused, I will get to it.
Here is the headlines.  go through the things that have set off alarm bells in your life.
ask if they are still necessary and turn off the alarms.
There are probably 20 of them.
the bladder hears them because it is the organ of “being present” you don’t hear them.
because they happen at a different level.  car alarms, disturbing get out of the building alarms.
mom was in assisted living and the alarms would go off 3-4 times a week!!!
(new construction)  it would set all her internal ones off.  she is very conscientious but who knew
to turn off disturbing reminders of things that are important.
got it?
You will then experience peace and the cells will take off their ear muffs. aka noice cancelling ear muffs.
and throw them away and all the toxins will leave.
Bravo will help with it all
being aware
coating and soothing
cleaning the toxins
filling the holes
helping you to see that its an alarm
dealing with the stress…
Bravo is a champ. and a friend.
I guess I am too!!!
hope this helps.
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Emulsification and Physical Health

Posted on June 22, 2016 by Mimi Castellanos

Oil and water don’t mix, unless they do.

Emulsifiers have been used to make the bridge between oil (or fats) and water.  This issue has become evident when cottage cheese turns into curds and whey.  What if our brains turn into “cottage cheese” and cease to the functioning agent it once was.

What I do to emulsify milk before I make Bravo GcMAF yogurt is to shake it.  It brings the milk looking happy again and being properly connected.  If it gets old or frozen.  (Yes, I do use frozen milk if I have to for my own batch.  It’s surprising how the yogini’s children don’t have any Bravo!)  When I did this, the liquid appeared to break.  I shook it but this time it wasn’t enough!  The liquid stayed broken or separated through out the batch.

To save it, I drained off the whey and saved the curd.  That worked okay but I had a jar of whey with no GcMAF and there was no turning back.  It was saved for the moment but I had to figure it all out.  This blog post is my learnings or musings.

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The Grass Roots Food Movement of Good Health: make your own fresh pressed seed oil.

Posted on June 19, 2016 by Mimi Castellanos

Of all the things that I have become fascinated with, fresh oil is one of my favorites.  It is one of those ingredients that if harnessed makes the difference between a world class chef prepared meal and all of the rest.  It is simply life changing.  It is delicious and undoubtably healthy for the body and like all goodness, you must attract it and work for it.

When I go to the farm to get fresh goat’s milk and I sample it, I believe that I can “taste” the grass in it!  But by the next day the depth and complexity are gone and instead, I have what is commonly known as milk.  Yet the allure of that fresh, complex, rich and deep taste will linger and be life changing if combined with other elements of  a meal.

The depth of the taste of the fresh oil is just as hard to describe.  I can taste what must be the life of the seed, its broken husk popped open, and its preciousness spilled.  But it isn’t there for very long.  I just wish others could have the chance to experience this fascinating experience but unless you are along side me while I am pressing, it will remain illusive because whatever “it” is, it breaks down very quickly.

The value is probably available in any “cold pressed” oil as the cells burst and give up their oil.  The explosion of life force is the key and it just doesn’t have all that movement after a few hours.  That is my best explanation.  The food still  has movement at a micro cellular level and it is of course the life force that feeds us!

Let me show you how to get that oil for yourself.  I purchased a hand turned screw press from Amazon.  It was made in the Netherlands. It is called a Piteba.  I don’t recommend it any more because it is just too hard to clean.  the seed press gets caught and you have to soak it out.  It isn’t an easy thing because you have to spend 20 mins cranking and heating.

Its fun to show kids how to do it close up.  But for use, I have moved on.  (see below)

This is what I use.  I use it for my food, I use it in and on my dinner and also for oil pulling right after dinner. (same time each day) So my cells can detoxify.  (Search Simply Mimi for oil pulling and Budwig)

On amazon, they have an electric one.  It has a heater on it to get the press casing warm to make the seeds easier to burst.  softens them but doesn’t heat the past “cold pressed”.

https://www.amazon.com/OrangeA-Press-Machine-Commercial-Olive/dp/B0727WXKV1/ref=cm_cr_arp_d_product_top?ie=UTF8

I bought this one when it was $500 in Oct of 2016 and don’t regret it.  I recommend this for anyone culinary who wants the magic of fresh pressed oil.  (within 1 hour).  I make some for my dinner, pull off the screw and casing and put them in the dishwasher.  The press is big and lives in my garage but it is so worth it.  I just have to get used to using it in short bursts.  Instead of keeping the oil in a jar, I keep the seeds pre-measured in a jar.  I also find I can add things like milk thistle seeds to clean the liver, cilantro seeds for a bit of spice, celery seed, etc. to build the herbs right into my oil.  Amazing.

I can pull the screw and the casing off with 4 bolts and put them in the dishwasher.  It’s part of making dinner for me!

You can always buy the “next best thing”.  Buy the magic (oleic acid) which we need for the Vit D channel and immune system, isn’t as present.  There is a special something that it has that is incredible if you can feel subtle energies.

Which is cold pressed pure fresh artisan level oil.  Here is where to buy it and how they make it:

If you are getting into oils, I recommend that you take a look into this nobel laureate for some keys!  It is available in a very neat package here:

Find out how essential healthy oils are to our health!!!  For more info about how to free yourself in this way, consider becoming an oil burning human!  See how that can self-actualize your psychological state as well!  Here we look into the work of this wonderful Russian physician whose autistic son nurtured (what I consider to be) a great work of art to enter this world.

I am an oil burning, ketogenic, leaf eating, fresh, complex, deep and well put together human being.  You are invited to be one too.  Take a deep breath, call in the Light for the Highest Good, and dive in!

It’s a beautiful world hey hey!!

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Parasite Cleanse Protocol

Posted on June 16, 2016 by Mimi Castellanos

This is an audio file from the Advanced call from Bravo from June 14, 2016.  It is a partial description to just help people who are starting to think about parasite cleanse.

http://www.freeconferencecalling.com/recordings/Recording.aspx?fileid=LA3977_06142016153127220_1086755&bridge=466134&email=&accountid=1351405

A few things to learn to manage/kill with parasites:  (If you just master one, you run the risk of getting reinfected and exhausted.   Do one if that’s all you can do, and use the energy you gain to do more.  Just don’t push too hard or do to much.  It is “practice” and needed!  Here is a rule!  Rule: colon needs to be open to eliminate toxins. Otherwise, the toxins will reabsorb and go into the blood and then through the kidneys . . .  again and again. . . . If you can’t get rid of toxins, you will be exhausted!

  1. To kill adult parasites I use:
    1. Purely Holistic Parasite cleanse (AMAZON),  I use 5 per day when I am in cleanse mode.  (These types of remedies need to be rotated.) https://www.amazon.com/gp/product/B0196VDUX2/ref=oh_aui_search_detailpage?ie=UTF8&psc=1
    2. The Bravo Yogurt (www.bravocoop.com) Using Bravo 2 oz in the morning and 2 oz at night, is like giving myself a healthy operating system update!  It (I) got my immune system out of auto immune and into a place where I could fight and remove my parasites. I had strength.  Perhaps not something that would make it up on the achievement board (because its hard to see that Bravo gave that to me. It always seems to be that we forget about weakness as soon as it goes away.) Then we forget to acknowledge how we got there which could lead to an interruption and a failure)  On Bravo, my achievements will make it to the achievement board!  I get things done that I definitely couldn’t do before!!! After about 9 months of taking Bravo, I consistently notice I can do more with no collapse.  I screw up and pay for it.  But I am human!  I am now a “human”worthy opponent to my attackers because if I don’t, these guys will win and weaken me and leave me in despair where I quickly trip over myself and fail.  WITH Bravo, I know that is not going to happen to me today!!!  I have certainty.  I seem to have clarity about what to do and don’t let the parasitic communication hormones get to me.  I shut them down by dedication to diet.  (more on diet below)
    3. OTC pin worm medication because it works and I am tired of them winning! I use Reese’s pin worm remedy (or the generic CVS brand is also very good) I use about 1 tbs daily for 3 weeks.  I will clean out the matrix homes of the parasites.  Warning: This med is intended for a single dose which clearly doesn’t work.  However, more will begin to dissolve not just the transportation tubes but the things that keep your blood vessels together and hair shafts standing erect.  I can’t risk going into cancer which is where this would go if I let it.  For me, this is a risk of damage/results.  As with all meds…
  2. Jelly nests – These little parasite homes have a biofilm around it.  In these nests, they lay 20,000 eggs per day.  This is part of their winning strategy which you must manage.   stop absorption of nutritens and ultimately shut down digestion. also can live in liver, brain, etc.  lymph may get clogged while eliminating but go slowly.  You must keep in tune with what you can eliminate!!
    1. I use Klaire Labs – Interfase Plus I bought it on amazon.  this cuts the jelly which is called bio-film.  Read the reviews for other things that people have used that work.  Don’t stop till it works FOR YOU.  Everyone is different.
    2. You will need some sort of “chelation” to move the bugs.  It is different for everyone but a few of them are:  JUST ONE!!!  these are really strong.
      1. MMS link – I use this with an enema bulb to get the jelly nests.  It works.  http://www.keavyscorner.com/MMS-CD-Kit-w-citric-acid-1-fl-oz-Glass-Bottles-p/kit-c1g.htm
      2. Food Grade 17% Hydrogen Peroxide
      3. EDTA
        1. more parents use topical transdermal DMSA creams (Keladine EDTA cream) and gluthanione gels on their autistic children. This approach, combined with MSM as a skin permeability enhancer, allows for heavy metals to be removed more slowly while lowering the risks of overdosing on any particular chelator, particularly in children.
      4. Good quality Vitamin C such as http://lovingsuperfoods.com/rawfood/naturalvitaminc.html
        1. Take it to “bowel tolerance”  which means loosening of the bowels which means take a bit more all the time  until you reach this stage then back down and hold it there for a little while so your body can clean.  Stop before you exhaust  yourself.  You should feel good.
      5. Plague remedy –  this one might be able to be used with others it is more food based and taints the food in your system so that bugs don’t want it.  Not bad!
        1. http://simplymimi.net/archives/778
  3. Parasite eggs –  Hulda Clark taught us about cloves to kill eggs and it works but not if they are hiding in the jelly nests!  Don’t take cloves unless you are using a biofilm cutter.  I use 15 cloves per day when I am in my 3-4 week cycle. Nothing can get to them in there.  so keep going with cloves and Jelly nest after you stop the pin worm remedy.
  4. reinfection of eggs   It is contagious so you have to be careful about vacuuming and changing sheets, etc, once you get to the end.   I use a tea tree oil shampoo which helps to kill them from the body.  but mostly, you just have to keep going and WIN
  5. diet – the parasites jack your communication system and tell you its FINE to eat chips, nuts, cheese.  etc, etc.  What?  That isn’t me?  Nope.  and they will get stronger.  Get yourself on a ketogenic diet!  Burn fats not sugars.  very different view of life.  You don’t have to change  your diet but there is a risk.  cancer eats sugar.  Nests can take up the cells and they can turn into cancer in the adolescent phases,  if you have ever been an adolescent, they are in charge of reproduction.  This is where they can get reckless and pull in tissue.  Why take the risk of starting cancer or continuing it.  Keep going giving yourself the strength to get better.  Do what works for you and  not what doesn’t
  6. The cancer part has to have negative frequencies.  Tune in (literally) to remove them. there is always a rattle snake under illness..  but if there is not, the cancer will not manifest it will be on the edge….  Get off the edge.  Keep going.

 

 

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